...screening appears to be finding many small tumors that would not be a problem if they were left alone, undiscovered by screening. They were destined to stop growing on their own or shrink, or even, at least in the case of some breast cancers, disappear.
Cancer cells and precancerous cells are so common that nearly everyone by middle age or old age is riddled with them, said Thea Tlsty, a professor of pathology at the University of California, San Francisco. That was discovered in autopsy studies of people who died of other causes, with no idea that they had cancer cells or precancerous cells. They did not have large tumors or symptoms of cancer. “The really interesting question,” Dr. Tlsty said, “is not so much why do we get cancer as why don’t we get cancer?”
I think the liklihood of cancerous cells disappearing on their own is very possible. My opinion as to why we don't get cancer? I think that goes all the way back to what happens at conception and early gestation, DNA methylation and associated genetic silencing - but that's just my opinion!
In Molecular Nutrition I learned that cancerous cells can be restored to health and/or eliminated from the body through cell apoptosis. The RNA and DNA of the mitochondria of the cell (where the cell is controlled) can be repaired. If the cell is too damaged or at the end of its life cycle complete apoptosis (cell death) can be achieved before damaged cells can develop pathology.
I noticed on your column the reference to Molecular Nutrition. The synthesis of cell wall material, and the lysosomes, which may contain enzymes involved in cell destruction have functions that are still uncertain, don't they?
I am not a professional in this area; just interested.
Lysosomes consist of a membrane-enclosed sac that contains several Enzymes that catalyze the digestion of various substances within Cells. Via this process, Lysosomes function as intracellular "waste disposal units":
Lysosomes catalyze the intracellular digestion of some Carbohydrates.
Lysosomes release Proteolytic Enzymes and Lipases that catalyze the destruction/removal of Lipofuscin from Cells.
Lysosomes catalyze the intracellular digestion of Nucleic Acids.
Lysosomes release Proteolytic Enzymes that catalyze the intracellular digestion of Proteins.
Lysosomes contain Acid Hydrolases and Lysozyme for release when required for intracellular digestion or for Immune System defense.
When the Lysosome's Membrane is disrupted Acid Hydrolases are released that destroy (digest) Antigens that have been engulfed by Phagocytes.
Free Radicals and Antigens that have been engulfed by Phagocytes may cause the excessive rupture of Lysosomes. Polyphenols would be indicated for the inhibition of Acid Hydrolases from Lysosomes. Quercetin and Hesperidin inhibit the release of Acid Hydrolases from Lysosomes.
Yes, I have read about the functions of the known and understood Lysosomes, but my point and question were more about something that can't be answered: that science still doesn't know enough about the synthesis of the cell wall, or enough about the various enzymes in the lysosomes to accurately know if cell death will occur. Also, it is not known what quantities of polyphenols are needed to act as inhibitors. I'm not arguing, just pointing out that the effects of these enzymes, free radicals, polyphenols are inconclusive and not a reliable source of information for cancer prevention/or causation.
Lysosomes do not function in a vacuum. 24 branched chain amino acids are required for the endogenous production of proteins that guide the genetic communication that controls production of oncogenes responsible for cancer. Essential fatty acids 3,6,9,12 are required to maintain a fluid cell wall that allows nutrients in and waste out.
You can't overdose on natural food sources of polyphenols. A nutritious, organic apple a day....just like the doctor ordered will do it.
Science is way behind the 8 ball....they just don't get it.
I get you, but no, I wasn't implying overdose, the problem is we don't know how much is needed. Thanks for the chat. All I have for today.
There is actually allot of research on polyphenols..If you want me to... I will pull the research together for you. Let me know.
Gozo, I was so short on 2.6. Had to run.
I haven't read just recently, but have spent time reading about certain aspects of cellular/molecular biology and how nutritional aspects affect the cells. (out of interest)
I have basic information on the polyphenols primarily from internet sources. That is very kind of you to offer to put some research together for me. I just don't want to see you waste your time right now because I have a few other directions I was getting involved in, primarily genetic mutations, DNA, and RNA in some viruses. I let myself side-track on a few other topics, and now my plate is full!
Having been involved with Equine nutrition (not anymore) is what started my research in your field. I'm still interested in nutrition, and am hoping to catch up with you or I can contact you in a few months. Would that be alright?
Absolutely, I look forward to it. Keep us posted on your research...sounds timely and interesting.
You're in Easy Mode. If you prefer, you can use XHTML Mode instead. |