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12 Votes
20 Comments
Drug May Help Smokers Quit...Moving to Phase III Trials
News Type: Event — Seeded on Tue Nov 10, 2009 2:29 PM EST
Article Source: CNNadvertisement
The NicVAX vaccine prompts the immune system to create antibodies that bind to the nicotine molecules in the blood. The now-larger molecules are prevented by their size from crossing the blood-brain barrier. Trapped outside the brain, the bound nicotine can't reach the receptors that trigger the release of dopamine. No dopamine, no pleasure.
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{"commentId":10599010,"authorDomain":"jcatom"}
Drug experts say nicotine is more difficult to kick than heroin. The American Cancer Society reports that of the 44 million smokers in the United States, 70 percent say they want to quit. About 40 percent do quit each year, but only 4 to 7 percent manage to give up smoking, without help, for good.
{"commentId":10599010,"threadId":"721107","contentId":"3486224","authorDomain":"jcatom"}
- 5 votes
#1 - Tue Nov 10, 2009 2:31 PM EST{"commentId":10599344,"authorDomain":"lalaland2013"}
This would be so fantastic, I've wanted to quit for ages but the patch and cold turkey trigger my migraines :(
I actually work for a Research Ethics Board at a hospital, so I think I might try to get into a Phase 3 trial if I can
{"commentId":10599344,"threadId":"721107","contentId":"3486224","authorDomain":"lalaland2013"}
- 4 votes
{"commentId":10602773,"authorDomain":"whatanoddguy"}
If cold turkey triggers migraines, this probably will as well. Both methods stop nicotine from getting to your brain.
{"commentId":10602773,"threadId":"721107","contentId":"3486224","authorDomain":"whatanoddguy"}
- 4 votes
{"commentId":10606828,"authorDomain":"lalaland2013"}
Agreed, oddguy, but if there's a real chance for longevity (as opposed to my cold turkey tries), I'm willing to brave it, ya know? My only other option would be laser surgery or hypnosis.
{"commentId":10606828,"threadId":"721107","contentId":"3486224","authorDomain":"lalaland2013"}
- 3 votes
{"commentId":10612119,"authorDomain":"Socrates1"}
So, desperate for nicotine, but the molecules won't make it to the brain......I just don't know.
{"commentId":10612119,"threadId":"721107","contentId":"3486224","authorDomain":"Socrates1"}
- 1 vote
{"commentId":10599771,"authorDomain":"gshaverpioneer"}
And side effects?
{"commentId":10599771,"threadId":"721107","contentId":"3486224","authorDomain":"gshaverpioneer"}
- 2 votes
#2 - Tue Nov 10, 2009 3:03 PM EST{"commentId":10603911,"authorDomain":"take2la"}
You mean like the other anti-smoking drugs which are GREAT at stopping smoking but equally GREAT at causing suicide as well.
{"commentId":10603911,"threadId":"721107","contentId":"3486224","authorDomain":"take2la"}
- 1 vote
{"commentId":10599842,"authorDomain":"src97531"}
I had excellent results with Chantix. Over a year now.
{"commentId":10599842,"threadId":"721107","contentId":"3486224","authorDomain":"src97531"}
- 3 votes
#3 - Tue Nov 10, 2009 3:05 PM EST{"commentId":10602476,"authorDomain":"zomzom"}
I quit by switching to nicotene gum. Which I got addicted to. Which I now chew when I can't go outside for a cigarette.
NOM NOM NOM. I love tobacco.
{"commentId":10602476,"threadId":"721107","contentId":"3486224","authorDomain":"zomzom"}
- 3 votes
#4 - Tue Nov 10, 2009 4:42 PM EST{"commentId":10603083,"authorDomain":"mars-9l"}
The easiest way to quit is to sack-up and quit. Put distance between yourself and people you know that smoke, as well as stay away from places where you know people will be smoking (like outside bars and clubs). People that say "I can't" are self-defeating and lack will-power (insert excuses here you self-defeaters). ANYONE can quit cold turkey. But you REALLY have to WANT IT! Trust me, you will ALWAYS want a smoke, even after you've quit for many, many years. The desire never goes away. It just becomes more and more manageable every day that you don't have one. Plus... Quitting Cold-turkey doesn't cost anything except maybe some withdrawal effects... And a headache is far better than coughing-up your lungs on your deathbed ;)
{"commentId":10603083,"threadId":"721107","contentId":"3486224","authorDomain":"mars-9l"}
- 3 votes
#5 - Tue Nov 10, 2009 5:03 PM EST{"commentId":10603632,"authorDomain":"rdonaldsnyder"}
I smoked for 33 years and quit 6 years ago (this January) by using the patch. Still it took me 6 months to wean myself off from the patch and it was hard to do. Still get the occasional cravings. I think the thing that made it possible was I decided to quit and it wasn't in response to anyone pushing me to do it.
{"commentId":10603632,"threadId":"721107","contentId":"3486224","authorDomain":"rdonaldsnyder"}
- 3 votes
#6 - Tue Nov 10, 2009 5:27 PM EST{"commentId":10603929,"authorDomain":"mars-9l"}
That's an excellent point! I too was pressured several times by loved-ones to quit but what really made it happen was doing it for myself :)
{"commentId":10603929,"threadId":"721107","contentId":"3486224","authorDomain":"mars-9l"}
- 3 votes
{"commentId":10605703,"authorDomain":"neenie1991"}
AutoTechDude,
I think it's terrific that you've quit but cold turkey doesn't work for everyone! It is an addiction and there are different means and tools that people can use to quit. It's not mind over matter for most people. I've tried cold turkey and had full on panic attacks, not fun. I can't take bupropion because of my other meds. I'm looking at behavior modification and patches right now. It's not an easy road for anyone, but I feel like it does a disservice to folks to tell them to just man up and quit or suck it up. Would we say that to an alcoholic or a heroin addict?
Based on the level of dependence, the most common measure for determining the addictiveness of a drug, the substances ranked as follows, from most to least addictive:
- Nicotine
- Heroin
- Cocaine
- Alcohol
- Caffeine
{"commentId":10605703,"threadId":"721107","contentId":"3486224","authorDomain":"neenie1991"}
- 3 votes
{"commentId":10605961,"authorDomain":"mars-9l"}
I concede your point neenie199... I guess I've never encountered anyone that had such a serious addiction to nicotine... other substances yes. But never nicotine. I understand it's addictive potential since I was once addicted myself but I have never equated that addiction to any others... I just feel like any "tools" that aren't "going to a meeting" or "talking to someone about it" are just ways that people can make more money off your addiction.
{"commentId":10605961,"threadId":"721107","contentId":"3486224","authorDomain":"mars-9l"}
- 2 votes
{"commentId":10606358,"authorDomain":"neenie1991"}
It's difficult to consider it or compare it to heroin, you look at a guy smoking a cigarette or a guy shooting up and it doesn't seem like the addiction could be the same. (Especially since one of them is legal) But our brains don't know the difference and unlike heroin or coke, we can go to 7-11 and get a fix. It's complicated.
My dad smoked 3 packs a day of Pall-Mall studs and did what you did. Stopped. Done. Holy Cow. I hate myself for not having quit/failed/trying. Statistically, it takes 5-7 tries before someone can successfully quit. But you have to TRY 5-7 times. Pffft. I didn't smoke for 4 days last week, doing great. Had a meltdown, (bi-polar meltdown) and got some smokes and here I am. Argh.
And I understand about the tools, patches, meds. and making money off of the addiction. I'd rather they make the money than the hospitals, doctors, mortuaries, et cetera. from the result of smoking.
{"commentId":10606358,"threadId":"721107","contentId":"3486224","authorDomain":"neenie1991"}
- 3 votes
{"commentId":10606489,"authorDomain":"mars-9l"}
It's ok neenie1991... just keep trying you'll kick the habit eventually... :)
{"commentId":10606489,"threadId":"721107","contentId":"3486224","authorDomain":"mars-9l"}
- 3 votes
{"commentId":10606963,"authorDomain":"neenie1991"}
I will.
I will.
I will.
;o)
{"commentId":10606963,"threadId":"721107","contentId":"3486224","authorDomain":"neenie1991"}
- 3 votes
{"commentId":10603939,"authorDomain":"nephthys"}
The thing is, people who quit using an aid (nicotine therapy, prescription drugs, etc) are much more likely to relapse and smoke again rather then those who quit without using an aid.
{"commentId":10603939,"threadId":"721107","contentId":"3486224","authorDomain":"nephthys"}
- 2 votes
#7 - Tue Nov 10, 2009 5:40 PM EST{"commentId":10604215,"authorDomain":"src97531"}
Don't know if that's true. You have any studies that back that up?
{"commentId":10604215,"threadId":"721107","contentId":"3486224","authorDomain":"src97531"}
- 3 votes
{"commentId":10604267,"authorDomain":"rdonaldsnyder"}
I used an aid (the patch) and haven't relapsed in nearly 6 years. Of course once I quit if I started to smoke again my wife would flat out kill me! She would cut my heart out with a dull knife and feed it to the dogs. So I have an incentive to stay smoke free.
;-)
{"commentId":10604267,"threadId":"721107","contentId":"3486224","authorDomain":"rdonaldsnyder"}
- 4 votes
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